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Specific neural substrate linking respiration to locomotion.

ABSTRACT: When animals move, respiration increases to adapt for increased energy demands; the underlying mechanisms are still not understood. We investigated the neural substrates underlying the respiratory changes in relation to movement in lampreys. We showed that respiration increases following stimulation of the mesencephalic locomotor region (MLR) in an in vitro isolated preparation, an effect that persists in the absence of the spinal cord and caudal brainstem. By using electrophysiological and anatomical techniques, including whole-cell patch recordings, we identified a subset of neurons located in the dorsal MLR that send direct inputs to neurons in the respiratory generator. In semi-intact preparations, blockade of this region with 6-cyano-7-nitroquinoxaline-2,3-dione and (2R)-amino-5-phosphonovaleric acid greatly reduced the respiratory increases without affecting the locomotor movements. These results show that neurons in the respiratory generator receive direct glutamatergic connections from the MLR and that a subpopulation of MLR neurons plays a key role in the respiratory changes linked to movement.

SUBMITTER: Gariepy JF

PROVIDER: S-EPMC3258635 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Specific neural substrate linking respiration to locomotion.

Gariépy Jean-François JF Missaghi Kianoush K Chevallier Stéphanie S Chartré Shannon S Robert Maxime M Auclair François F Lund James P JP Dubuc Réjean R

Proceedings of the National Academy of Sciences of the United States of America 20111212 2

When animals move, respiration increases to adapt for increased energy demands; the underlying mechanisms are still not understood. We investigated the neural substrates underlying the respiratory changes in relation to movement in lampreys. We showed that respiration increases following stimulation of the mesencephalic locomotor region (MLR) in an in vitro isolated preparation, an effect that persists in the absence of the spinal cord and caudal brainstem. By using electrophysiological and anat ...[more]

PMID: 22160700

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Specific neural substrate linking respiration to locomotion.

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Specific neural substrate linking respiration to locomotion.

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