Dataset Information

Enhanced cardiac PI3K? signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.

ABSTRACT:

Aims

Cardiac hypertrophy and heart failure are associated with QT prolongation and lethal ventricular arrhythmias resulting from decreased K(+) current densities and impaired repolarization. Recent studies in mouse models of physiological cardiac hypertrophy revealed that increased phosphoinositide-3-kinase-? (PI3K?) signalling results in the up-regulation of K(+) channels and the normalization of ventricular repolarization. The experiments here were undertaken to test the hypothesis that increased PI3K? signalling will counteract the adverse electrophysiological remodelling associated with pathological hypertrophy and heart failure.

Methods and results

In contrast to wild-type mice, left ventricular (LV) hypertrophy, induced by transverse aortic constriction (TAC), did not result in prolongation of ventricular action potentials or QT intervals in mice with cardiac-specific expression of constitutively active PI3K? (caPI3K?). Indeed, repolarizing K(+) currents and K(+) channel subunit transcripts were increased in caPI3K? + TAC LV myocytes in proportion to the TAC-induced cellular hypertrophy. Congestive heart failure in a transgenic model of dilated cardiomyopathy model is accompanied by prolonged QT intervals and ventricular action potentials, reduced K(+) currents and K(+) channel transcripts. Increased PI3K? signalling, but not renin-angiotensin system blockade, in this model also results in increased K(+) currents and improved ventricular repolarization.

Conclusion

In the setting of pathological hypertrophy or heart failure, enhanced PI3K? signalling results in the up-regulation of K(+) channel subunits, normalization of K(+) current densities and preserved ventricular function. Augmentation of PI3K? signalling, therefore, may be a useful and unique strategy to protect against the increased risk of ventricular arrhythmias and sudden death associated with cardiomyopathy.

SUBMITTER: Yang KC

PROVIDER: S-EPMC3258651 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.

Yang Kai-Chien KC Jay Patrick Y PY McMullen Julie R JR Nerbonne Jeanne M JM

Cardiovascular research 20111027 2

<h4>Aims</h4>Cardiac hypertrophy and heart failure are associated with QT prolongation and lethal ventricular arrhythmias resulting from decreased K(+) current densities and impaired repolarization. Recent studies in mouse models of physiological cardiac hypertrophy revealed that increased phosphoinositide-3-kinase-α (PI3Kα) signalling results in the up-regulation of K(+) channels and the normalization of ventricular repolarization. The experiments here were undertaken to test the hypothesis tha ...[more]

PMID: 22038742

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