Ontology highlight
ABSTRACT:
SUBMITTER: Tsai CY
PROVIDER: S-EPMC3258916 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Tsai Ching-Yen CY Chou Chen-Kung CK Yang Chu-Wen CW Lai Yi-Chen YC Liang Chih-Chia CC Chen Chun-Ming CM Tsai Ting-Fen TF
The Journal of biological chemistry 20080801 39
First revealed in cancer studies, HURP (hepatoma up-regulated protein) is a cell cycle-associated gene with elevated expression in the G(2)/M phase. Cell culture studies have revealed that HURP is an essential factor required for spindle formation and chromosome congression during mitosis. However, the function of HURP in an in vivo context has not been explored. We generated a Hurp knock-out (Hurp(-/-)) mouse to investigate the role of HURP in development under normal physiological conditions. ...[more]