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ABSTRACT:
SUBMITTER: Laskin J
PROVIDER: S-EPMC3259225 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Laskin Julia J Heath Brandi S BS Roach Patrick J PJ Cazares Lisa L Semmes O John OJ
Analytical chemistry 20111201 1
Ambient ionization imaging mass spectrometry is uniquely suited for detailed spatially resolved chemical characterization of biological samples in their native environment. However, the spatial resolution attainable using existing approaches is limited by the ion transfer efficiency from the ionization region into the mass spectrometer. Here, we present a first study of ambient imaging of biological samples using nanospray desorption ionization (nano-DESI). Nano-DESI is a new ambient pressure io ...[more]