Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
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ABSTRACT:
SUBMITTER: Deo AJ
PROVIDER: S-EPMC3259283 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
Deo Anthony J AJ Cahill Michael E ME Li Siyu S Goldszer Isaac I Henteleff Ruth R Vanleeuwen Jon-Eric JE Rafalovich Igor I Gao Ruoqi R Stachowski Erin K EK Sampson Allan R AR Lewis David A DA Penzes Peter P Sweet Robert A RA
Neurobiology of disease 20111113 2
Reductions in dendritic arbor length and complexity are among the most consistently replicated changes in neuronal structure in post mortem studies of cerebral cortical samples from subjects with schizophrenia, however, the underlying molecular mechanisms have not been identified. This study is the first to identify an alteration in a regulatory protein which is known to promote both dendritic length and arborization in developing neurons, Kalirin-9. We found Kalirin-9 expression to be paradoxic ...[more]
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