Ontology highlight
ABSTRACT:
SUBMITTER: Stuible M
PROVIDER: S-EPMC3259645 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Stuible Matthew M Dubé Nadia N Tremblay Michel L ML
The Journal of biological chemistry 20080403 23
The emergence of protein-tyrosine phosphatase 1B (PTP1B) as a potential drug target for treatment of diabetes, obesity, and cancer underlies the importance of understanding its full range of cellular functions. Here, we have identified cortactin, a central regulator of actin cytoskeletal dynamics, as a substrate of PTP1B. A trapping mutant of PTP1B binds cortactin at the phosphorylation site Tyr(446), the regulation and function of which have not previously been characterized. We show that phosp ...[more]