Ontology highlight
ABSTRACT:
SUBMITTER: Mahul-Mellier AL
PROVIDER: S-EPMC3259881 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Mahul-Mellier Anne-Laure AL Strappazzon Flavie F Petiot Anne A Chatellard-Causse Christine C Torch Sakina S Blot Béatrice B Freeman Kimberley K Kuhn Loriane L Garin Jérome J Verna Jean-Marc JM Fraboulet Sandrine S Sadoul Rémy R
The Journal of biological chemistry 20081020 50
Alix/AIP1 regulates cell death in a way involving interactions with the calcium-binding protein ALG-2 and with proteins of ESCRT (endosomal sorting complex required for transport). Using mass spectrometry we identified caspase-8 among proteins co-immunoprecipitating with Alix in dying neurons. We next demonstrated that Alix and ALG-2 interact with pro-caspase-8 and that Alix forms a complex with the TNFalpha receptor-1 (TNF-R1), depending on its capacity to bind ESCRT proteins. Thus, Alix and AL ...[more]