Ontology highlight
ABSTRACT:
SUBMITTER: Tropini C
PROVIDER: S-EPMC3260198 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tropini Carolina C Roth Elizabeth A EA Zanic Marija M Gardner Melissa K MK Howard Jonathon J
PloS one 20120117 1
Microtubules are dynamic polymers of GTP- and GDP-tubulin that undergo stochastic transitions between growing and shrinking phases. Rescues, the conversion from shrinking to growing, have recently been proposed to be to the result of regrowth at GTP-tubulin islands within the lattice of growing microtubules. By introducing mixed GTP/GDP/GMPCPP (GXP) regions within the lattice of dynamic microtubules, we reconstituted GXP islands in vitro (GMPCPP is the slowly hydrolyzable GTP analog guanosine-5' ...[more]