Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota.

ABSTRACT:

Background

The integration of host genetics, environmental triggers and the microbiota is a recognised factor in the pathogenesis of barrier function diseases such as IBD. In order to determine how these factors interact to regulate the host immune response and ecological succession of the colon tissue-associated microbiota, we investigated the temporal interaction between the microbiota and the host following disruption of the colonic epithelial barrier.

Methodology/principal findings

Oral administration of DSS was applied as a mechanistic model of environmental damage of the colon and the resulting inflammation characterized for various parameters over time in WT and Nod2 KO mice.

Results

In WT mice, DSS damage exposed the host to the commensal flora and led to a mi

SUBMITTER: Smith P 

PROVIDER: S-EPMC3260280 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature