Ontology highlight
ABSTRACT:
SUBMITTER: Eren E
PROVIDER: S-EPMC3260308 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Eren Elif E Vijayaraghavan Jagamya J Liu Jiaming J Cheneke Belete R BR Touw Debra S DS Lepore Bryan W BW Indic Mridhu M Movileanu Liviu L van den Berg Bert B
PLoS biology 20120117 1
Many Gram-negative bacteria, including human pathogens such as Pseudomonas aeruginosa, do not have large-channel porins. This results in an outer membrane (OM) that is highly impermeable to small polar molecules, making the bacteria intrinsically resistant towards many antibiotics. In such microorganisms, the majority of small molecules are taken up by members of the OprD outer membrane protein family. Here we show that OprD channels require a carboxyl group in the substrate for efficient transp ...[more]