Ontology highlight
ABSTRACT:
SUBMITTER: Powers RJ
PROVIDER: S-EPMC3260783 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Powers Richard J RJ Roy Sitikantha S Atilgan Erdinc E Brownell William E WE Sun Sean X SX Gillespie Peter G PG Spector Alexander A AA
Biophysical journal 20120101 2
In hair cells, although mechanotransduction channels have been localized to tips of shorter stereocilia of the mechanically sensitive hair bundle, little is known about how force is transmitted to the channel. Here, we use a biophysical model of the membrane-channel complex to analyze the nature of the gating spring compliance and channel arrangement. We use a triangulated surface model and Monte Carlo simulation to compute the deformation of the membrane under the action of tip link force. We s ...[more]