Association of candidate genes with phenotypic traits relevant to anorexia nervosa.
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ABSTRACT:
SUBMITTER: Root TL
PROVIDER: S-EPMC3261131 | biostudies-literature | 2011 Nov-Dec
REPOSITORIES: biostudies-literature
Publications
Association of candidate genes with phenotypic traits relevant to anorexia nervosa.
Root Tammy L TL Szatkiewicz Jin P JP Jonassaint Charles R CR Thornton Laura M LM Pinheiro Andrea Poyastro AP Strober Michael M Bloss Cinnamon C Berrettini Wade W Schork Nicholas J NJ Kaye Walter H WH Bergen Andrew W AW Magistretti Pierre P Brandt Harry H Crawford Steve S Crow Scott S Fichter Manfred M MM Goldman David D Halmi Katherine A KA Johnson Craig C Kaplan Allan S AS Keel Pamela K PK Klump Kelly L KL La Via Maria M Mitchell James E JE Rotondo Alessandro A Treasure Janet J Woodside D Blake DB Bulik Cynthia M CM
European eating disorders review : the journal of the Eating Disorders Association 20110721 6
This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at mena ...[more]
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2023-10-31 | GSE245978 | GEO
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Project description:BackgroundSeveral lines of evidence indicate that the central cannabinoid receptor 1 (CNR1) as well as the major endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH), N-acylethanolamine-hydrolyzing acid amidase (NAAA) and monoglyceride lipase (MGLL) are implicated in mediating the orexigenic effects of cannabinoids. The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN).MethodsWe analysed the association of a previously described (AAT)n repeat in the 3' flanking region of CNR1 as well as a total of 15 single nucleotide polymorphisms (SNPs) representative of regions with restricted haplotype diversity in CNR1, FAAH, NAAA or MGLL in up to 91 German AN trios (patient with AN and both biological parents) using the transmission-disequilibrium-test (TDT). One SNP was additionally analysed in an independent case-control study comprising 113 patients with AN and 178 normal weight controls. Genotyping was performed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, ARMS-PCR or using 3730xl capillary sequencers.ResultsThe TDT revealed no evidence for association for any of the SNPs or the (AAT)n repeat with AN (all two-sided uncorrected p-values > 0.05). The lowest p-value of 0.11 was detected for the A-allele of the CNR1 SNP rs1049353 for which the transmission rate was 59% (95% confidence interval 47%...70%). Further genotyping of rs1049353 in 113 additional independent patients with AN and 178 normal weight controls could not substantiate the initial trend for association (p = 1.00).ConclusionAs we found no evidence for an association of genetic variation in CNR1, FAAH, NAAA and MGLL with AN, we conclude that genetic variations in these genes do not play a major role in the etiology of AN in our study groups.
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