Prevalence of congenital anomalies in infants with in utero exposure to antiretrovirals.

ABSTRACT:

Background

Although use of efficacious interventions, including antiretrovirals (ARVs), has dramatically reduced the rate of mother-to-child transmission of human immunodeficiency virus, the safety of in utero ARV exposure remains of concern.

Methods

Data regarding 1112 infants enrolled in the International Maternal Pediatric Adolescent AIDS Clinical Trials Group protocol P1025 born between 2002 and 2007 were analyzed for this study. Congenital anomalies were classified based on the Metropolitan Atlanta Congenital Defects Program guidelines. Associations between congenital anomalies and timing of first in utero exposure to ARVs were evaluated by logistic regression analysis.

Results

Congenital anomalies were identified and confirmed in 61 of the 1112 infants, resultin

SUBMITTER: Knapp KM 

PROVIDER: S-EPMC3261302 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature