Ontology highlight
ABSTRACT:
SUBMITTER: Cellurale C
PROVIDER: S-EPMC3261359 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Cellurale Cristina C Girnius Nomeda N Jiang Feng F Cavanagh-Kyros Julie J Lu Shaolei S Garlick David S DS Mercurio Arthur M AM Davis Roger J RJ
Cancer research 20111129 2
cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clear ...[more]