Unknown

Dataset Information

0

Role of JNK in mammary gland development and breast cancer.


ABSTRACT: cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clearance of lumenal epithelial cells. In the setting of breast cancer development, JNK1/2 deficiency significantly increased tumor formation. Together, these findings established that JNK signaling is required for normal mammary gland development and that it has a suppressive role in mammary tumorigenesis.

SUBMITTER: Cellurale C 

PROVIDER: S-EPMC3261359 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Role of JNK in mammary gland development and breast cancer.

Cellurale Cristina C   Girnius Nomeda N   Jiang Feng F   Cavanagh-Kyros Julie J   Lu Shaolei S   Garlick David S DS   Mercurio Arthur M AM   Davis Roger J RJ  

Cancer research 20111129 2


cJun NH(2)-terminal kinase (JNK) signaling has been implicated in the developmental morphogenesis of epithelial organs. In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast development and tumorigenesis. JNK1/2 was not required for breast epithelial cell proliferation or motility. However, JNK1/2 deficiency caused increased branching morphogenesis and defects in the clear  ...[more]

Similar Datasets

| S-EPMC4560637 | biostudies-literature
| S-EPMC7352995 | biostudies-literature
| S-EPMC4153917 | biostudies-literature
| S-EPMC3692603 | biostudies-literature
| S-EPMC7228762 | biostudies-literature
| S-EPMC5354691 | biostudies-literature
| S-EPMC2694958 | biostudies-literature
| S-EPMC5897596 | biostudies-literature
| S-EPMC3500637 | biostudies-literature
| S-EPMC7294649 | biostudies-literature