Ontology highlight
ABSTRACT:
SUBMITTER: Glatter T
PROVIDER: S-EPMC3261712 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Glatter Timo T Schittenhelm Ralf B RB Rinner Oliver O Roguska Katarzyna K Wepf Alexander A Jünger Martin A MA Köhler Katja K Jevtov Irena I Choi Hyungwon H Schmidt Alexander A Nesvizhskii Alexey I AI Stocker Hugo H Hafen Ernst E Aebersold Ruedi R Gstaiger Matthias M
Molecular systems biology 20111108
Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway. However, the biochemical context of this regulatory system is still poorly characterized in Drosophila. Here, we present the first quantitative study that systematically characterizes the modularity and hormone sensitivity of the interaction ...[more]