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Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis.

ABSTRACT: BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR?), a nuclear receptor, has been implicated playing a role in the development of inflammatory bowel disease (IBD). However, previous studies evaluating the association between the PPAR?2 Pro12Ala polymorphism and IBD are inconsistent. We performed a meta-analysis to determine whether the PPAR?2 Pro12Ala mutation was associated with the presence of IBD. METHODS AND FINDINGS: Electronic databases were searched for case-control studies evaluating the association between the Pro12Ala mutation and the presence of IBD. Effects were summarized with the methods recommended by the Cochrane Collaboration. A total of 7 studies including 1002 ulcerative colitis (UC) cases, 1090 Croh?s disease (CD) cases and 1983 controls were involved in this meta-analysis. In the overall analysis, no significant association of this polymorphism with UC or CD was found. In the subgroup analyses in different populations, AlaAla genotype seemed to protect the European Caucasian population against the development of CD (Pro vs Ala: OR?=?1.135, 95%CI?=?0.951-1.354, P?=?0.162, Bon?=?1.000; ProPro vs ProAla: OR?=?1.042, 95%CI?=?0.852-1.273, P?=?0.690, Bon?=?1.000; ProPro vs AlaAla: OR?=?2.379, 95%CI?=?1.110-5.100, P?=?0.026, Bon?=?0.156; ProAla vs AlaAla: OR?=?2.315, 95%CI?=?1.064-5.037, P?=?0.034, Bon?=?0.204; Pro homozygotes vs Ala positives: OR?=?1.094, 95%CI?=?0.899-1.330, P?=?0.371, Bon?=?1.000; Pro positives vs Ala homozygotes: OR?=?2.360, 95%CI?=?1.103-5.053, P?=?0.027, Bon?=?0.162; heterozygotes vs all homozygotes: OR?=?0.976, 95%CI?=?0.799-1.192, P?=?0.809, Bon?=?1.000). There was no significant association of this polymorphism with UC or CD in the East Asian population and the Turkish population. CONCLUSION: AlaAla genotype may be a protective factor in the European Caucasian population against the development of CD in a recessive way.

SUBMITTER: Zhang ZF

PROVIDER: S-EPMC3261897 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis.

Zhang Zhi-Feng ZF Yang Ning N Zhao Gang G Zhu Lei L Wang Li-Xia LX

PloS one 20120119 1

<h4>Background</h4>Peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor, has been implicated playing a role in the development of inflammatory bowel disease (IBD). However, previous studies evaluating the association between the PPARγ2 Pro12Ala polymorphism and IBD are inconsistent. We performed a meta-analysis to determine whether the PPARγ2 Pro12Ala mutation was associated with the presence of IBD.<h4>Methods and findings</h4>Electronic databases were searched for case- ...[more]

PMID: 22276212

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Project description:IntroductionPrematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment strategies. A growing body of evidence suggest that peroxisome proliferator-activated receptor gamma (PPARγ) signaling is associated with inhibited brain development in preterm babies. The Ala allele of the Pro12Ala polymorphism of PPARγ2 decreases receptor binding affinity and consequently induces a reduction of PPARγ signaling.MethodsIn this study, we carried out a preliminary analysis of existing datasets to test the hypothesis that reduced transactivation capacity of PPARγ in the presence of the Ala variant of PPARγ2 may be associated with adverse neurodevelopment in preterm babies. The association between PPAR-γ2 Pro12Ala polymorphism and neurodevelopment at 18-24 months of age was assessed in two groups of European infants, 155 born before 33 weeks' gestation and 180 born later than 36 weeks' gestation using a linear regression model. The Bayley Scales of Infant and Toddler Development-3rd edition was administered to assess neurodevelopment at 18-24 months of age.ResultsWe observed the Ala allele of the Pro12Ala polymorphism in 25% preterm infants and 20% term infants. The Ala allele of PPARγ2 was significantly associated with adverse cognitive (p = .019), language (p = .03), and motor development (p = 0.036) at 18-24 months of age after taking into consideration the duration of ventilation, gender, and index of multiple deprivation scores, but without correction for potential shared ancestry. There was no association between the PPAR-γ2 Pro12Ala polymorphism and neurodevelopment in term infants.ConclusionsThese preliminary data suggest that PPARγ signaling in the presence of the Ala variant of PPARγ2 may be associated with adverse neurodevelopment in preterm infants suggesting that further studies are warranted.

Dataset Information

Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis.

Publications

Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis.

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