Ontology highlight
ABSTRACT:
SUBMITTER: Hudjetz B
PROVIDER: S-EPMC3262014 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Hudjetz Ben B Gabriel Gülsah G
PLoS pathogens 20120119 1
Influenza A viruses may cross species barriers and transmit to humans with the potential to cause pandemics. Interplay of human- (PB2 627K) and avian-like (PB2 627E) influenza polymerase complexes with unknown host factors have been postulated to play a key role in interspecies transmission. Here, we have identified human importin-α isoforms (α1 and α7) as positive regulators of human- but not avian-like polymerase activity. Human-like polymerase activity correlated with efficient recruitment of ...[more]