Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Leal O
PROVIDER: S-EPMC3262670 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Perez-Leal Oscar O Moncada Camilo C Clarkson Allen B AB Merali Salim S
American journal of respiratory cell and molecular biology 20110603 6
Pneumocystis pneumonia (PCP) is a life-threatening condition in immunosuppressed patients. Current treatments are inadequate, and new drug leads are needed. This fungus depends on its host for S-adenosylmethionine (AdoMet), a critical metabolic intermediate ordinarily synthesized by individual cells as needed. Pneumocystis contains a gene coding for the AdoMet-synthesizing enzyme methionine ATP transferase (MAT), and the protein is expressed. However, the fungus lacks MAT activity, and infection ...[more]