Ontology highlight
ABSTRACT:
SUBMITTER: van Gils JM
PROVIDER: S-EPMC3262880 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
van Gils Janine M JM Derby Merran C MC Fernandes Luciana R LR Ramkhelawon Bhama B Ray Tathagat D TD Rayner Katey J KJ Parathath Sajesh S Distel Emilie E Feig Jessica L JL Alvarez-Leite Jacqueline I JI Rayner Alistair J AJ McDonald Thomas O TO O'Brien Kevin D KD Stuart Lynda M LM Fisher Edward A EA Lacy-Hulbert Adam A Moore Kathryn J KJ
Nature immunology 20120108 2
Atherosclerotic plaque formation is fueled by the persistence of lipid-laden macrophages in the artery wall. The mechanisms by which these cells become trapped, thereby establishing chronic inflammation, remain unknown. Here we found that netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated the migration of macrophages toward chemokines linked to their egress from plaques. Acting via its receptor, UNC5b, netrin-1 inhibited the migrat ...[more]