Ontology highlight
ABSTRACT:
SUBMITTER: Kwiatkowski N
PROVIDER: S-EPMC3262907 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
ACS chemical biology 20111021 1
The members of the Aurora kinase family play critical roles in the regulation of the cell cycle and mitotic spindle assembly and have been intensively investigated as potential targets for a new class of anticancer drugs. We describe a new highly potent and selective class of Aurora kinase inhibitors discovered using a phenotypic cellular screen. Optimized inhibitors display many of the hallmarks of Aurora inhibition including endoreduplication, polyploidy, and loss of cell viability in cancer c ...[more]