Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
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ABSTRACT:
SUBMITTER: Loh K
PROVIDER: S-EPMC3263335 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Loh Kim K Fukushima Atsushi A Zhang Xinmei X Galic Sandra S Briggs Dana D Enriori Pablo J PJ Simonds Stephanie S Wiede Florian F Reichenbach Alexander A Hauser Christine C Sims Natalie A NA Bence Kendra K KK Zhang Sheng S Zhang Zhong-Yin ZY Kahn Barbara B BB Neel Benjamin G BG Andrews Zane B ZB Cowley Michael A MA Tiganis Tony T
Cell metabolism 20111013 5
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of "leptin resistance." Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and development of cellular leptin resistance. Here we report that hypothalamic levels of the tyrosine phosphatase TCPTP are also elevated in obesity to attenuate the leptin response. We show that mice that lack TCPTP in neuronal cells have enhanced leptin sensitivi ...[more]
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