Regulation of SIRT6 protein levels by nutrient availability.
Ontology highlight
ABSTRACT:
SUBMITTER: Kanfi Y
PROVIDER: S-EPMC3263697 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Regulation of SIRT6 protein levels by nutrient availability.
Kanfi Yariv Y Shalman Ronnie R Peshti Victoria V Pilosof Shmuel N SN Gozlan Yosi M YM Pearson Kevin J KJ Lerrer Batya B Moazed Danesh D Marine Jean-Christophe JC de Cabo Rafael R de Cabo Rafael R Cohen Haim Y HY
FEBS letters 20080131 5
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the ...[more]
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