Ontology highlight
ABSTRACT:
SUBMITTER: Riveline JP
PROVIDER: S-EPMC3263906 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Riveline Jean-Pierre JP Rousseau Elise E Reznik Yves Y Fetita Sabrina S Philippe Julien J Dechaume Aurélie A Hartemann Agnès A Polak Michel M Petit Catherine C Charpentier Guillaume G Gautier Jean-François JF Froguel Philippe P Vaxillaire Martine M
Diabetes care 20111230 2
<h4>Objective</h4>Gain-of-function ABCC8/sulfonylurea (SU) receptor 1 mutations cause neonatal diabetes mellitus (NDM) or late-onset diabetes in adult relatives. Given the effectiveness of SU treatment in ABCC8-NDM patients, we further characterized late-onset ABCC8-associated diabetes.<h4>Research design and methods</h4>Seven adult subjects from three NDM families and one family with type 2 diabetes were studied. Insulin secretion and insulin sensitivity were assessed using clamp techniques. We ...[more]