Ontology highlight
ABSTRACT:
SUBMITTER: Grigoryan G
PROVIDER: S-EPMC3264056 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Grigoryan Gevorg G Kim Yong Ho YH Acharya Rudresh R Axelrod Kevin K Jain Rishabh M RM Willis Lauren L Drndic Marija M Kikkawa James M JM DeGrado William F WF
Science (New York, N.Y.) 20110501 6033
There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recogn ...[more]