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Computational design of virus-like protein assemblies on carbon nanotube surfaces.


ABSTRACT: There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recognition and favorable intersubunit packing interactions. This procedure is exemplified in the design of peptides that assemble into a tubular structure surrounding single-walled carbon nanotubes (SWNTs). The geometrically defined, virus-like coating created by these peptides converts the smooth surfaces of SWNTs into highly textured assemblies with long-scale order, capable of directing the assembly of gold nanoparticles into helical arrays along the SWNT axis.

SUBMITTER: Grigoryan G 

PROVIDER: S-EPMC3264056 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Computational design of virus-like protein assemblies on carbon nanotube surfaces.

Grigoryan Gevorg G   Kim Yong Ho YH   Acharya Rudresh R   Axelrod Kevin K   Jain Rishabh M RM   Willis Lauren L   Drndic Marija M   Kikkawa James M JM   DeGrado William F WF  

Science (New York, N.Y.) 20110501 6033


There is a general need for the engineering of protein-like molecules that organize into geometrically specific superstructures on molecular surfaces, directing further functionalization to create richly textured, multilayered assemblies. Here we describe a computational approach whereby the surface properties and symmetry of a targeted surface define the sequence and superstructure of surface-organizing peptides. Computational design proceeds in a series of steps that encode both surface recogn  ...[more]

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