Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii.
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SUBMITTER: Poirel L
PROVIDER: S-EPMC3264265 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii.
Poirel Laurent L Bonnin Rémy A RA Boulanger Anne A Schrenzel Jacques J Kaase Martin M Nordmann Patrice P
Antimicrobial agents and chemotherapy 20111205 2
A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissem ...[more]
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