Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: Grau T
PROVIDER: S-EPMC3264283 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.
Grau Thomas T Selchow Petra P Tigges Marcel M Burri Reto R Gitzinger Marc M Böttger Erik C EC Fussenegger Martin M Sander Peter P
Antimicrobial agents and chemotherapy 20111121 2
Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of ethionamide, isoxyl, and thiacetazone in Mycobacterium tuberculosis strains with resistance to ETH due to inhA promoter mutations but not ethA mutations. ...[more]
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