Generation of chimeric rhesus monkeys.
Ontology highlight
ABSTRACT:
SUBMITTER: Tachibana M
PROVIDER: S-EPMC3264685 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Generation of chimeric rhesus monkeys.
Tachibana Masahito M Sparman Michelle M Ramsey Cathy C Ma Hong H Lee Hyo-Sang HS Penedo Maria Cecilia T MC Mitalipov Shoukhrat S
Cell 20120105 1-2
Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent cells and can differentiate into any cell type of a body except extraembryonic tissues. The ability to contribute to chimeric animals upon reintroduction into host embryos is the key feature of murine totipotent and pluripotent cells. Here, we dem ...[more]
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