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Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

ABSTRACT: Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-behavioral stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat.One hundred ninety-nine women undergoing primary treatment of stage 0-III breast cancer were randomized to a 10-week CBSM protocol or an active control condition. Seventy-nine provided peripheral blood leukocyte samples for genome-wide transcriptional profiling and bioinformatic analyses at baseline, 6-month, and 12-month follow-ups.Baseline negative affect was associated with >50% differential expression of 201 leukocyte transcripts, including upregulated expression of pro-inflammatory and metastasis-related genes. CBSM altered leukocyte expression of 91 genes by >50% at follow-up (group × time interaction), including downregulation of pro-inflammatory and metastasis-related genes and upregulation of type I interferon response genes. Promoter-based bioinformatic analyses implicated decreased activity of NF-?B/Rel and GATA family transcription factors and increased activity of interferon response factors and the glucocorticoid receptor as potential mediators of CBSM-induced transcriptional alterations.In early-stage breast cancer patients, a 10-week CBSM intervention can reverse anxiety-related upregulation of pro-inflammatory gene expression in circulating leukocytes. These findings clarify the molecular signaling pathways by which behavioral interventions can influence physical health and alter peripheral inflammatory processes that may reciprocally affect brain affective and cognitive processes.

SUBMITTER: Antoni MH

PROVIDER: S-EPMC3264698 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

Antoni Michael H MH Lutgendorf Susan K SK Blomberg Bonnie B Carver Charles S CS Lechner Suzanne S Diaz Alain A Stagl Jamie J Arevalo Jesusa M G JM Cole Steven W SW

Biological psychiatry 20111116 4

<h4>Background</h4>Chronic threat and anxiety are associated with pro-inflammatory transcriptional profiles in circulating leukocytes, but the causal direction of that relationship has not been established. This study tested whether a cognitive-behavioral stress management (CBSM) intervention targeting negative affect and cognition might counteract anxiety-related transcriptional alterations in people confronting a major medical threat.<h4>Methods</h4>One hundred ninety-nine women undergoing pri ...[more]

PMID: 22088795

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Project description:Background:Children with high level of preoperative anxiety during their visit to dental office are more likely to develop maladaptive behavior postoperatively. First dental experience is always critical in molding child's attitude toward dentistry. Various behavior management methods are being employed during dental treatment to complete anticipated treatment in children. Aim:The aim of the study was to evaluate the effectiveness of cognitive behavioral play therapy and audiovisual distraction for management of preoperative anxiety in children. Materials and methods:A total of 45 children of age 6-10 years with moderate-to-severe anxiety were allocated into three groups: group I-cognitive behavioral play therapy (CBT), group II-audiovisual (AV) distraction, and group III-tell-show-do technique (control group). Children in the CBT group were allowed to play with building blocks, asked to draw a picture and then showed a modeling video of co-operative child undergoing dental treatment. Children in group II were subjected to passive distraction with audiovisual aids, whereas group III (control) children were managed with the conventional TSD technique. Baseline and postintervention objective and subjective anxiety scores were measured with a pulse oximeter and facial image scale (FIS), respectively. Results:A statistically significant reduction in the subjective and objective anxiety scores is observed in all the three groups (p = 0.001) in both intragroup and intergroup comparisons. On intergroup comparison, the reduction in subjective and objective anxiety scores was higher in CBT (p = 0.0) than in AV distraction and TSD groups (p = 0.05). Conclusion:Active distraction with cognitive behavioral play therapy is found to be more effective in reducing the preoperative anxiety in children compared to audiovisual distraction and tell-show-do technique. Clinical significance:Identification and management of preoperative anxiety in children is most critical for successful dental treatment. Active distraction is an effective psychological approach for behavior management in anxious children. How to cite this article:Rajeswari SR, Chandrasekhar R, Vinay C, et al. Effectiveness of Cognitive Behavioral Play Therapy and Audiovisual Distraction for Management of Preoperative Anxiety in Children. Int J Clin Pediatr Dent 2019;12(5):419-422.

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Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

Publications

Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

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