Ontology highlight
ABSTRACT:
SUBMITTER: Thompson AA
PROVIDER: S-EPMC3264755 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Thompson Aaron A AA Liu Jeffrey J JJ Chun Eugene E Wacker Daniel D Wu Huixian H Cherezov Vadim V Stevens Raymond C RC
Methods (San Diego, Calif.) 20111021 4
The biophysical characterization of purified membrane proteins typically requires detergent mediated extraction from native lipid membrane environments. In the case of human G protein-coupled receptors (GPCRs), this process has been complicated by their conformational heterogeneity and the general lack of understanding the composition and interactions within the diverse human cellular membrane environment. Several successful GPCR structure determination efforts have shown that the addition of ch ...[more]