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Synthetic Studies Towards MPC1001: Preparation of a ?-hydroxyl-Tyrosine Derivative.

ABSTRACT: A procedure for the asymmetric synthesis of a novel ?-hydroxy-?-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde.

SUBMITTER: Schuber PT

PROVIDER: S-EPMC3265114 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Synthetic Studies Towards MPC1001: Preparation of a β-hydroxyl-Tyrosine Derivative.

Schuber Paul T PT Williams Robert M RM

Tetrahedron letters 20120101 4

A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyama aldol reaction via a diphenyloxazinone and 3-bromo-4-methoxybenzaldehyde. ...[more]

PMID: 22287813

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