Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110?.
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ABSTRACT:
SUBMITTER: Perino A
PROVIDER: S-EPMC3265115 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Perino Alessia A Ghigo Alessandra A Ferrero Enrico E Morello Fulvio F Santulli Gaetano G Baillie George S GS Damilano Federico F Dunlop Allan J AJ Pawson Catherine C Walser Romy R Levi Renzo R Altruda Fiorella F Silengo Lorenzo L Langeberg Lorene K LK Neubauer Gitte G Heymans Stephane S Lembo Giuseppe G Wymann Matthias P MP Wetzker Reinhard R Houslay Miles D MD Iaccarino Guido G Scott John D JD Hirsch Emilio E
Molecular cell 20110401 1
Adrenergic stimulation of the heart engages cAMP and phosphoinositide second messenger signaling cascades. Cardiac phosphoinositide 3-kinase p110γ participates in these processes by sustaining β-adrenergic receptor internalization through its catalytic function and by controlling phosphodiesterase 3B (PDE3B) activity via an unknown kinase-independent mechanism. We have discovered that p110γ anchors protein kinase A (PKA) through a site in its N-terminal region. Anchored PKA activates PDE3B to en ...[more]
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