Ontology highlight
ABSTRACT:
SUBMITTER: Diakos C
PROVIDER: S-EPMC3265147 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Diakos Christofer C Zhong Sheng S Xiao Yuanyuan Y Zhou Mi M Vasconcelos Gisele M GM Krapf Gerd G Yeh Ru-Fang RF Zheng Shichun S Kang Michelle M Wiencke John K JK Pombo-de-Oliveira Maria S MS Pombo-de-Oliveira Maria S MS Panzer-Grümayer Renate R Wiemels Joseph L JL
Blood 20100831 23
There is increasing evidence that miRNA and transcription factors interact in an instructive fashion in normal and malignant hematopoiesis. We explored the impact of TEL-AML1 (ETV6-RUNX1), the most common fusion protein in childhood leukemia, on miRNA expression and the leukemic phenotype. Using RNA interference, miRNA expression arrays, and quantitative polymerase chain reaction, we identified miRNA-494 and miRNA-320a to be up-regulated upon TEL-AML1 silencing independently of TEL expression. C ...[more]