Ontology highlight
ABSTRACT:
SUBMITTER: Isaev D
PROVIDER: S-EPMC3265164 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Isaev Dmytro D Zhao Qian Q Kleen Jonathan K JK Lenck-Santini Pierre Pascal PP Adstamongkonkul Dusit D Isaeva Elena E Holmes Gregory L GL
Epilepsia 20110302 3
Interictal spikes have been implicated in epileptogenesis and cognitive dysfunction in epilepsy. Unfortunately, antiepileptic drugs have shown poor efficacy in suppressing interictal discharges; novel therapies are needed. Surface charge on neuronal membranes provides a novel target for abolishing interictal spikes. This property can be modulated through the use of neuraminidase, an enzyme that decreases the amount of negatively charged sialic acid. In the present report we determined whether ap ...[more]