Unknown

Dataset Information

0

Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking.

ABSTRACT: Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA(A) receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.

SUBMITTER: Pei YF 

PROVIDER: S-EPMC3266269 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking.

Pei Yu-Fang YF   Zhang Lei L   Yang Tie-Lin TL   Han Yingying Y   Hai Rong R   Ran Shu S   Tian Qing Q   Shen Hui H   Li Jian J   Zhu Xue-Zhen XZ   Luo Xingguang X   Deng Hong-Wen HW  

PloS one 20120125 1

Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array  ...[more]

Similar Datasets

Unknown Genome-wide association study identified copy number variants important for appendicular lean mass.
| S-EPMC3953533 | biostudies-literature
Unknown Rare copy number variants are an important cause of epileptic encephalopathies.
| S-EPMC3245646 | biostudies-literature
Unknown Copy number variants in Ebstein anomaly.
| S-EPMC5720705 | biostudies-other
Unknown Genome-wide association studies for economically important traits in mink using copy number variation.
| S-EPMC10762091 | biostudies-literature
Unknown A genome-wide assessment of rare copy number variants in colorectal cancer.
| S-EPMC4694911 | biostudies-literature
Unknown Genome-wide analysis of copy number variants in age-related macular degeneration.
| S-EPMC3613489 | biostudies-literature
Unknown Proteome-wide copy-number estimation from transcriptomics
| S-SCDT-10_1038-S44320-024-00064-3 | biostudies-other
Unknown A genome-wide study reveals copy number variants exclusive to childhood obesity cases.
| S-EPMC2978976 | biostudies-literature
Genomics Somatic copy number alterations associating with alcohol drinking and smoking in head and neck squamous cell carcinoma
2013-07-01 | GSE47443 | GEO
Unknown A genome-wide scan of copy number variants in three Iranian indigenous river buffaloes.
| S-EPMC8077898 | biostudies-literature