Ontology highlight
ABSTRACT:
SUBMITTER: Thapa N
PROVIDER: S-EPMC3266520 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Thapa Narendra N Sun Yue Y Schramp Mark M Choi Suyong S Ling Kun K Anderson Richard A RA
Developmental cell 20120101 1
Polarized delivery of signaling and adhesion molecules to the leading edge is required for directional migration of cells. Here, we describe a role for the PIP(2)-synthesizing enzyme, PIPKIγi2, in regulation of exocyst complex control of cell polarity and polarized integrin trafficking during migration. Loss of PIPKIγi2 impaired directional migration, formation of cell polarity, and integrin trafficking to the leading edge. Upon initiation of directional migration, PIPKIγi2 via PIP(2) generation ...[more]