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Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis.

ABSTRACT: The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure(®)) coating were shown to inhibit macrophage adhesion; no signs of coating delamination were noted over a 48-h period.

SUBMITTER: Miller PR

PROVIDER: S-EPMC3266534 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis.

Miller Philip R PR Skoog Shelby A SA Edwards Thayne L TL Lopez Deanna M DM Wheeler David R DR Arango Dulce C DC Xiao Xiaoyin X Brozik Susan M SM Wang Joseph J Polsky Ronen R Narayan Roger J RJ

Talanta 20111122

The development of a microneedle-based biosensor array for multiplexed in situ detection of exercise-induced metabolic acidosis, tumor microenvironment, and other variations in tissue chemistry is described. Simultaneous and selective amperometric detection of pH, glucose, and lactate over a range of physiologically relevant concentrations in complex media is demonstrated. Furthermore, materials modified with a cell-resistant (Lipidure(®)) coating were shown to inhibit macrophage adhesion; no si ...[more]

PMID: 22265568

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