Benefits associated with achieving optimal risk factor levels for the primary prevention of cardiovascular disease in older men.

ABSTRACT:

Background

Most incident cardiovascular disease (CVD) occurs after patients reach the age of 65. The additive benefits of aggressive risk factor management with advancing age are not well established.

Objective

To evaluate the relationship between control of four modifiable risk factors (smoking, non-high density lipoprotein cholesterol, blood pressure, and aspirin use) and risk of CVD in a primary prevention population of older men.

Materials and methods

U.S. male physicians from the Physicians' Health Study (n = 4182; an epidemiologic follow-up of a randomized trial of aspirin and beta-carotene) who in 1997 were ≥ 65 years, free of CVD and diabetes, and had a blood sample on file were studied. Cox proportional hazard models were adjusted for age and competing causes

SUBMITTER: Robinson JG 

PROVIDER: S-EPMC3266543 | biostudies-literature | 2012 Jan-Feb

REPOSITORIES: biostudies-literature