Ontology highlight
ABSTRACT:
SUBMITTER: McMullen PD
PROVIDER: S-EPMC3266876 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
McMullen Patrick D PD Aprison Erin Z EZ Winter Peter B PB Amaral Luis A N LA Morimoto Richard I RI Ruvinsky Ilya I
PLoS computational biology 20120126 1
A major goal of systems biology is to understand how organism-level behavior arises from a myriad of molecular interactions. Often this involves complex sets of rules describing interactions among a large number of components. As an alternative, we have developed a simple, macro-level model to describe how chronic temperature stress affects reproduction in C. elegans. Our approach uses fundamental engineering principles, together with a limited set of experimentally derived facts, and provides q ...[more]