Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC3267750 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lu Yilu Y Zhang Kun K Li Chao C Yao Youlin Y Tao Dachang D Liu Yunqiang Y Zhang Sizong S Ma Yongxin Y
PloS one 20120127 1
Piwi proteins have been implicated in germ cell proliferation, differentiation, germline stem cell maintenance and transposon control in germline from Drosophila to mammals. The Piwi-like2 (piwil2) gene is mainly expressed in testis or embryonic cells among normal tissues but widely expressed in tumors. However, it remains to be fully determined through which mechanism piwil2 is involved in tumorigenesis. Here we report that Human piwil2, or Hili represses the tumor suppressor P53 in human cance ...[more]