Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
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ABSTRACT:
SUBMITTER: Subramaniam S
PROVIDER: S-EPMC3267880 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
Subramaniam Srinivasa S Napolitano Francesco F Mealer Robert G RG Kim Seyun S Errico Francesco F Barrow Roxanne R Shahani Neelam N Tyagi Richa R Snyder Solomon H SH Usiello Alessandro A
Nature neuroscience 20111218 2
L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor improvement on L-DOPA treatment, suggesting a therapeutic benefit for Rhes-binding dru ...[more]
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