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In search of a consensus model of the resting state of a voltage-sensing domain.

ABSTRACT: Voltage-sensing domains (VSDs) undergo conformational changes in response to the membrane potential and are the critical structural modules responsible for the activation of voltage-gated channels. Structural information about the key conformational states underlying voltage activation is currently incomplete. Through the use of experimentally determined residue-residue interactions as structural constraints, we determine and refine a model of the Kv channel VSD in the resting conformation. The resulting structural model is in broad agreement with results that originate from various labs using different techniques, indicating the emergence of a consensus for the structural basis of voltage sensing.

SUBMITTER: Vargas E

PROVIDER: S-EPMC3268064 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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In search of a consensus model of the resting state of a voltage-sensing domain.

Vargas Ernesto E Bezanilla Francisco F Roux Benoît B

Neuron 20111201 5

Voltage-sensing domains (VSDs) undergo conformational changes in response to the membrane potential and are the critical structural modules responsible for the activation of voltage-gated channels. Structural information about the key conformational states underlying voltage activation is currently incomplete. Through the use of experimentally determined residue-residue interactions as structural constraints, we determine and refine a model of the Kv channel VSD in the resting conformation. The ...[more]

PMID: 22153369

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