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PGAP: pan-genomes analysis pipeline.


ABSTRACT: SUMMARY: With the rapid development of DNA sequencing technology, increasing bacteria genome data enable the biologists to dig the evolutionary and genetic information of prokaryotic species from pan-genome sight. Therefore, the high-efficiency pipelines for pan-genome analysis are mostly needed. We have developed a new pan-genome analysis pipeline (PGAP), which can perform five analytic functions with only one command, including cluster analysis of functional genes, pan-genome profile analysis, genetic variation analysis of functional genes, species evolution analysis and function enrichment analysis of gene clusters. PGAP's performance has been evaluated on 11 Streptococcus pyogenes strains. AVAILABILITY: PGAP is developed with Perl script on the Linux Platform and the package is freely available from http://pgap.sf.net. CONTACT: junyu@big.ac.cn; xiaojingfa@big.ac.cn SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3268234 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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PGAP: pan-genomes analysis pipeline.

Zhao Yongbing Y   Wu Jiayan J   Yang Junhui J   Sun Shixiang S   Xiao Jingfa J   Yu Jun J  

Bioinformatics (Oxford, England) 20111129 3


<h4>Summary</h4>With the rapid development of DNA sequencing technology, increasing bacteria genome data enable the biologists to dig the evolutionary and genetic information of prokaryotic species from pan-genome sight. Therefore, the high-efficiency pipelines for pan-genome analysis are mostly needed. We have developed a new pan-genome analysis pipeline (PGAP), which can perform five analytic functions with only one command, including cluster analysis of functional genes, pan-genome profile an  ...[more]

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