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Differential roles of human striatum and amygdala in associative learning.

ABSTRACT: Although the human amygdala and striatum have both been implicated in associative learning, only the striatum's contribution has been consistently computationally characterized. Using a reversal learning task, we found that amygdala blood oxygen level-dependent activity tracked associability as estimated by a computational model, and dissociated it from the striatal representation of reinforcement prediction error. These results extend the computational learning approach from striatum to amygdala, demonstrating their complementary roles in aversive learning.

SUBMITTER: Li J

PROVIDER: S-EPMC3268261 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Differential roles of human striatum and amygdala in associative learning.

Li Jian J Schiller Daniela D Schoenbaum Geoffrey G Phelps Elizabeth A EA Daw Nathaniel D ND

Nature neuroscience 20110911 10

Although the human amygdala and striatum have both been implicated in associative learning, only the striatum's contribution has been consistently computationally characterized. Using a reversal learning task, we found that amygdala blood oxygen level-dependent activity tracked associability as estimated by a computational model, and dissociated it from the striatal representation of reinforcement prediction error. These results extend the computational learning approach from striatum to amygdal ...[more]

PMID: 21909088

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