Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.
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ABSTRACT:
SUBMITTER: Stecher B
PROVIDER: S-EPMC3268327 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.
Stecher Bärbel B Denzler Rémy R Maier Lisa L Bernet Florian F Sanders Mandy J MJ Pickard Derek J DJ Barthel Manja M Westendorf Astrid M AM Krogfelt Karen A KA Walker Alan W AW Ackermann Martin M Dobrindt Ulrich U Thomson Nicholas R NR Hardt Wolf-Dietrich WD
Proceedings of the National Academy of Sciences of the United States of America 20120109 4
The mammalian gut harbors a dense microbial community interacting in multiple ways, including horizontal gene transfer (HGT). Pangenome analyses established particularly high levels of genetic flux between Gram-negative Enterobacteriaceae. However, the mechanisms fostering intraenterobacterial HGT are incompletely understood. Using a mouse colitis model, we found that Salmonella-inflicted enteropathy elicits parallel blooms of the pathogen and of resident commensal Escherichia coli. These blooms ...[more]
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