Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.
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ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC3269124 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.
Xiao Ying Y Allen Emily C EC Silverman Scott K SK
Chemical communications (Cambridge, England) 20101201 6
A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn(2+) and Mn(2+) is switched by only two nucleotide mutations to require Zn(2+) alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor. ...[more]
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