Ontology highlight
ABSTRACT:
SUBMITTER: Gall A
PROVIDER: S-EPMC3269499 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gall Alevtina A Treuting Piper P Elkon Keith B KB Loo Yueh-Ming YM Gale Michael M Barber Glen N GN Stetson Daniel B DB
Immunity 20120101 1
The type I interferon (IFN) response initiated by detection of nucleic acids is important for antiviral defense but is also associated with specific autoimmune diseases. Mutations in the human 3' repair exonuclease 1 (Trex1) gene cause Aicardi-Goutières syndrome (AGS), an IFN-associated autoimmune disease. However, the source of the type I IFN response and the precise mechanisms of disease in AGS remain unknown. Here, we demonstrate that Trex1 is an essential negative regulator of the STING-depe ...[more]