Dataset Information

Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study.

ABSTRACT:

Objective

To investigate whether testosterone administration alters natriuretic peptide levels in women.

Design

Three-month, double-blind, randomized, placebo-controlled study.

Setting

Clinical research center.

Patient(s)

Fifty-one women with hypoandrogenemia due to hypopituitarism.

Intervention(s)

Transdermal testosterone (300 ?g daily) or placebo patch.

Main outcome measure(s)

N-Terminal pro-B-type natriuretic peptide (NT-proBNP) levels.

Result(s)

NT-proBNP levels decreased in the transdermal testosterone group compared with placebo over three months. The difference between groups remained significant after controlling for baseline age, systolic blood pressure, body mass index, and homeostasis model assessment of insulin resistance. Change in NT-proBNP over 3 months was inversely associated with change in free testosterone levels.

Conclusion(s)

Testosterone administration to women results in decreased natriuretic peptide levels, suggesting that testosterone may be an inverse regulator of the natriuretic peptide system.

Clinical trials registration number

NCT00027430.

SUBMITTER: Lin E

PROVIDER: S-EPMC3269509 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study.

Lin Eleanor E McCabe Elizabeth E Newton-Cheh Christopher C Bloch Kenneth K Buys Emmanuel E Wang Thomas T Miller Karen K KK

Fertility and sterility 20111202 2

<h4>Objective</h4>To investigate whether testosterone administration alters natriuretic peptide levels in women.<h4>Design</h4>Three-month, double-blind, randomized, placebo-controlled study.<h4>Setting</h4>Clinical research center.<h4>Patient(s)</h4>Fifty-one women with hypoandrogenemia due to hypopituitarism.<h4>Intervention(s)</h4>Transdermal testosterone (300 μg daily) or placebo patch.<h4>Main outcome measure(s)</h4>N-Terminal pro-B-type natriuretic peptide (NT-proBNP) levels.<h4>Result(s)< ...[more]

PMID: 22137497

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Project description:BackgroundAcupuncture is a potential conservative therapy for women with stress urinary incontinence (SUI). There is limited evidence to support its effectiveness due to the poor quality of existing studies.MethodsWe performed a pilot randomized, controlled trial to preliminarily assess the efficacy of electroacupuncture (EA) in women with pure SUI. A total of 80 women with pure SUI were randomly assigned to receive EA with deep needling at BL33 and BL35 (n = 40) or sham EA with non-penetrating needling at sham acupoints (n = 40) three sessions per week for 6 weeks. The women were followed for 24 weeks. The primary outcome was the change from baseline in the amount of urine leakage measured by a 1-hour pad test after 6 weeks. The secondary outcomes included the 72-hour incontinence episode frequency (IEF), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score, and patient self-evaluation of therapeutic effect. Adverse events (AEs) were monitored throughout the trial.ResultsThe median decrease from baseline of urine leakage measured by the 1-hour pad test was 2.5 g [interquartile range (IQR): 1.80-14.6 in the EA group, which was greater than the median decrease of 0.05 g (IQR: -2.80-+0.50) in the sham EA group after 6 weeks (p<0.01). The differences between groups in the decrease from baseline of 72-hour IEF became statistically significant at week 30 with a median decrease of 3.25 g (IQR: 1.25-5.69) in the EA group, and a median decrease of 1.00 g (IQR: -0.69-+2.88) in the sham EA group (p = 0.01). The participants in the EA group showed greater decreases in ICIQ-SF score and higher ratings in the help they received from the treatment than those in the sham EA group at weeks 6,18 and 30 (all p<0.05). No obvious AEs were observed in either group.ConclusionEA may effectively and safely relieve urinary incontinence symptoms and improve quality of life in women with pure SUI. EA demonstrated more than a placebo effect. Since this is a pilot study, results should be interpreted with caution.Trial registrationClinicalTrials.gov NCT02445573.

Dataset Information

Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study.

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Clinical trials registration number

Publications

Effects of transdermal testosterone on natriuretic peptide levels in women: a randomized placebo-controlled pilot study.

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