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Dissociation of motor and sensory inhibition processes in normal aging.

ABSTRACT: Age-related cognitive impairments have been attributed to deficits in inhibitory processes that mediate both motor restraint and sensory filtering. However, behavioral studies have failed to show an association between tasks that measure these distinct types of inhibition. In the present study, we hypothesized neural markers reflecting each type of inhibition may reveal a relationship across inhibitory domains in older adults.Electroencephalography (EEG) and behavioral measures were used to explore whether there was an across-participant correlation between sensory suppression and motor inhibition. Sixteen healthy older adult participants (65-80 years) engaged in two separate experimental paradigms: a selective attention, delayed-recognition task and a stop-signal task.Findings revealed no significant relationship existed between neural markers of sensory suppression (P1 amplitude; N170 latency) and markers of motor inhibition (N2 and P3 amplitude and latency) in older adults.These distinct inhibitory domains are differentially impacted in normal aging, as evidenced by previous behavioral work and the current neural findings. Thus a generalized inhibitory deficit may not be a common impairment in cognitive aging.Given that some theories of cognitive aging suggest age-related failure of inhibitory mechanisms may span different modalities, the present findings contribute to an alternative view where age-related declines within each inhibitory modality are unrelated.

SUBMITTER: Anguera JA

PROVIDER: S-EPMC3269557 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Dissociation of motor and sensory inhibition processes in normal aging.

Anguera Joaquin A JA Gazzaley Adam A

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20111001 4

<h4>Objective</h4>Age-related cognitive impairments have been attributed to deficits in inhibitory processes that mediate both motor restraint and sensory filtering. However, behavioral studies have failed to show an association between tasks that measure these distinct types of inhibition. In the present study, we hypothesized neural markers reflecting each type of inhibition may reveal a relationship across inhibitory domains in older adults.<h4>Methods</h4>Electroencephalography (EEG) and beh ...[more]

PMID: 21963321

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Project description:Previous studies have delineated the neural processes of motor response inhibition during a stop signal task, with most reports focusing on the cortical mechanisms. A recent study highlighted the importance of subcortical processes during stop signal inhibition in 13 individuals and suggested that the subthalamic nucleus (STN) may play a role in blocking response execution (Aron and Poldrack, 2006. Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus. J Neurosci 26, 2424-2433). Here in a functional magnetic resonance imaging (fMRI) study we replicated the finding of greater activation in the STN during stop (success or error) trials, compared to go trials, in a larger sample of subjects (n=30). However, since a contrast between stop and go trials involved processes that could be distinguished from response inhibition, the role of subthalamic activity during stop signal inhibition remained to be specified. To this end we followed an alternative strategy to isolate the neural correlates of response inhibition (Li et al., 2006a. Imaging response inhibition in a stop signal task--neural correlates independent of signal monitoring and post-response processing. J Neurosci 26, 186-192). We compared individuals with short and long stop signal reaction time (SSRT) as computed by the horse race model. The two groups of subjects did not differ in any other aspects of stop signal performance. We showed greater activity in the short than the long SSRT group in the caudate head during stop successes, as compared to stop errors. Caudate activity was positively correlated with medial prefrontal activity previously shown to mediate stop signal inhibition. Conversely, bilateral thalamic nuclei and other parts of the basal ganglia, including the STN, showed greater activation in subjects with long than short SSRT. Thus, fMRI delineated contrasting roles of the prefrontal-caudate and striato-thalamic activities in mediating motor response inhibition.

Dataset Information

Dissociation of motor and sensory inhibition processes in normal aging.

Publications

Dissociation of motor and sensory inhibition processes in normal aging.

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