Ontology highlight
ABSTRACT:
SUBMITTER: Ceolin L
PROVIDER: S-EPMC3269683 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ceolin Lucieli L Siqueira Débora R DR Romitti Mírian M Ferreira Carla V CV Maia Ana Luiza AL
International journal of molecular sciences 20111227 1
Medullary thyroid carcinoma is a rare malignant tumor originating in parafollicular C cells. It accounts for 5 to 8% of all thyroid cancers. MTC develops in either sporadic (75%) or hereditary form (25%). Genetic and molecular studies have demonstrated the involvement of the RET proto-oncogene in hereditary MTC and, less often, in its sporadic form. Although a strong genotype-phenotype correlation has been described, wide clinical heterogeneity is observed among families with the same RET mutati ...[more]