A phase II trial of huperzine A in mild to moderate Alzheimer disease.
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ABSTRACT:
SUBMITTER: Rafii MS
PROVIDER: S-EPMC3269774 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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A phase II trial of huperzine A in mild to moderate Alzheimer disease.
Rafii M S MS Walsh S S Little J T JT Behan K K Reynolds B B Ward C C Jin S S Thomas R R Aisen P S PS
Neurology 20110401 16
<h4>Objective</h4>Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD).<h4>Methods</h4>We assessed the safety, tolerability, and efficacy of huperzine A in mild to moderate AD in a multicenter trial in which 210 individuals were randomized to receive placebo (n = 70) or huperzine A (200 μg BID [n = 70] or 400 μg BID [n = 70]), for ...[more]
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